Following in the footsteps of her parents, Wesley became interested in performance at an early age. She loved to twirl her baton in local parades and took dance lessons at the West Las Vegas Arts Center. But it wasn't until she appeared in a production of Fame during her freshman year of high school at the Las Vegas Academy of International Studies, Performing and Visual Arts that she decided she wanted to pursue a career in acting. At the school she ended up starring in a number of productions, as well as studying theater and dance.
"I was born to be on stage," Wesley has said. "I loved storytelling. I was always making up stuff. I feel like that was my path."
Following her graduation in 1997, Wesley enrolled at Indiana's University of Evansville, where she obtained her B.F.A. in Theatre Performance in 2001. She then auditioned for the Juilliard School's Drama Division, where she was accepted in 2001. While there, she performed in classical theater productions such as Macbeth and The Marriage of Figaro. After honing her chops there, Wesley spent a summer studying Shakespeare at the Royal Academy of Dramatic Art in London, where she landed one of the title roles in a production of Romeo and Juliet.
In 2008, Wesley made her film debut as the lead in How She Move, which received critical acclaim. She got her big break, however, in 2007 as Tara Thornton in the HBO series True Blood, her debut television performance. Over the course of its run, the show has earned a number of accolades and garnered Wesley and her co-stars a Screen Actors Guild award nomination for Outstanding Ensemble in a Drama Series.
Wesley has said she would like to continue pursuing a film career in the coming years. "I would love to do some [romantic comedies], some action flicks," she said in a 2010 interview.
Wesley is married to actor Jacob Fishel and currently splits her time between Los Angeles and New York.